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d The Rios Group  

Recently, the quest of Asymmetric Methodologies have emerged as one of the cornerstones of organic chemistry. The synthesis of complex scaffolds with multiple stereogenic centers has become an enormous challenge for organic chemists. In our research group, we aim to develop new asymmetric methodologies based in Organometallic chemistry and Organocatalysis.

Our research is focused on the development of new methodologies, design of new catalysts or catalytic systems, application of organocatalysis to the synthesis of natural or biologically interesting compounds and the study of the mechanism of organocatalytic reactions.


November 2017: Our latest work in Synergistic Catalysis is online. Congratulations Marta. Victor and Pedro.


November 2017: Our work regarding the synthesis of spirolactams have been highlighted in Organic Chemistry highlights!!!

May 2017: A funded PhD position in our group is open for EU/UK students. The PhD will deal with the synthesis of new polymers for optoelectronic applications and asymmetric synthesis.

To apply: https://jobs.soton.ac.uk/Vacancy.aspx?ref=853517EB

February 2017: Our review regarding the uses of vinyl cyclopropanes is online, Congratulations Marta.

Synthetic Applications of Vinyl Cyclopropane Opening


February 2017: Our last paper in organocatalysis is online, Congratulations Kai, Marta and Jan's group.

Highly Diastereo and Enantioselective Synthesis of α-spiro-δ-lactams via Organocascade Reaction


January 2017: Our last paper in organocatalysis is online, Congratulations Marta and Mike.

Highly Enantioselective Synthesis of Alkylpyridine Derivatives through a Michael/Michael/Aldol Cascade Reaction



November 2016: Our last paper in synergistic catalysis is online, Congratulations Kai, Marta, Clotilde and Anabel.

Synergistic Catalysis: Asymmetric Synthesis of Cyclopentanes Bearing Four Stereogenic Centers



May 2016: Marta Meazza got an Honorable Mention in the ABTA Doctoral Researcher Awards. Congratulations, A well deserved prize for your exceptional work!!.

May 2016: Our Our last paper in Synergistic Catalysis is online. Congratulations Marta!!

Synergistic Catalysis: Enantioselective Ring Expansion of Vinyl Cyclopropanes combining 4 catalytic cycles. Synthesis of spiro-cyclopentanes bearing up to 4 stereocenters


May 2016: After finishing her PhD Dr. Marta Meazza started a postdoc in the group of PRofessor Karl Anker Jorgensen in Aarhus. Congratulations and good luck!!!

April 2016: Our Our last paper in organocatalysis is online. Synthesis of cyclopropanes using benzyl chlorides. Congratulations Marta, Maria and Yang's group!!



February 2016: Marta Meazza get her PhD degree!!!! Well done!!! Great Job!!!

February 2016: Our Our last paper in photocatalysis is online. Synthesis of phophoramidates using organic dyes. Congratulations Marta, Agga and Luke!!


January 2016: Our Review in Synthesis is online: Merging transition-Metal activation and Aminocatalysis. Congratulations Marta!!



January 2016: Our last paper of Photocatalysis has been accepted in ChemistrySelect. Great job Luke, Victor and Marta!!!!


October 2015: Our last paper of Synergistic catalysis is accepted in Chemical Science. Great job Marta!!!!


October 2015: A new paper have been published. Our collaboration with Professor Hao Guo (Fudan University) is working very well and here is our second common paper in Tetrahedron Letters. Congratulations to Guo's group!!!!

TL 2015

October 2015: Marta Meazza have been selected for a poster presentation at the Royal Society of Chemistry's Organic Division Poster Symposium 2015!!!! Congratulations!!!

October 2015: Our last paper about anthrones has been accepted in Scientific Reports. Congratulations Victor, Marta, Greg, Jiri and Jan!!!!!


May 2015: Lecture in East China Normal University. Visiting my good friend Professor Jian Zhao!!! Great time in China and remembering our postdoc with Professor Benjamin List!!!


May 2015: Our latest Molecules is online. Congratulations Victor, Tope and Marta!!!!

“Highly Diastereoselective Synthesis of Spiropyrazolones”



April 2015: Marta Meazza have been selected to give a talk at the 26th SCI Regional Postgraduate Symposium at Southampton on Novel Organic Chemistry. http://www.soci.org/Events/Display-Event?EventCode=FCHEM451 Congratulations Marta!!!

March 2015: Our article "Synergistic Catalysis: Enantioselective Addition of Alkylbenzoxazoles to Enals " (Chem. Eur. J. 2014, 20, 16853-16857) have been highlighted in SYNFACTS. Congratulations Marta and Victor!!!!

January 2015: Our article "Enantioselective Organocatalytic Synthesis of Fluorinated Molecules" (Chem. Eur. J. 2011, 17, 2018–2037) is among the top 20 most cited Reviews in Chemistry—A European Journal of the past 20 years!!! Congratulations Guillem and Xavi!!!!!


October 2014: Our latest Chemistry European Journal is online. Congratulations Marta and Victor!!!

Synergistic Catalysis: Enantioselective Addition of Alkylbenzoxazoles to Enals


In good company: A novel catalytic enantioselective methodology based on synergistic catalysis is reported. The strategy involves: 1) the metal-Lewis-acid activation of alkylazaarenes, and 2) the secondary-amine activation of enals (see scheme). Consequently, highly functionalized chiral

October 2014: Nice Review about our organocatalysis book in Angewandte

September 2014: Our latest paper on Synergistic Catalysis have been accepted in Chemistry European Journal!!! Congratulations Marta and Victor.

September 2014: A new paper have been published. Our collaboration with Professor Robert Raja is working very well and here s our first common paper in Catalysis Science and Technology: Congratulations to Raja's group!!!!

Highly effective design strategy for the heterogenisation of chemo- and enantioselective organocatalysts

August 2014: Marta and Victor have attended to the ACS Meeting 2014 in San Francisco where they presented their lasts works.

May 2014: Our latest Chemical Communnications is online. Congratulations to Victor, Marta and Piotr!!!

Synergistic catalysis: Highly diastereoselective benzoxazole addition to Morita–Baylis-Hillman carbonates



An expedited method has been developed for the diastereoselective synthesis of highly functionalized alkyl-azaarene systems with good yields and high diastereoselectivities (> 15:1 dr). The methodology includes a synergistic catalysis event involving organometallic (10 mol% AgOAc) activation of an alkyl azaarene and Lewis base (10 mol% DABCO) activation of a Morita–Baylis–Hillman carbonate. The structure and relative configuration of a representative product were confirmed by X-ray analysis


March 2014: Satoshi Okusu from Shibata's group has started a one month placement in our research group. Welcome!!!

February 2014: Dong Wang and Hun Yi Shin from Yang's group have started a one month placement in our research group. Welcome!!!!

January 2014: Our latest Advance Synthesis and Catalyst is online. Congratulations to Yang's team and Bing

Expanding the Scope of the Organocatalytic Addition of Fluorobis(phenylsulfonyl)methane to Enals: Enantioselective Cascade Synthesis of Fluoroindane and Fluorochromanol Derivatives


Thumbnail image of graphical abstract

Highly enantioselective cascade reactions for the synthesis of fluoroindanes and chromanols derivatives are described. The cascade reactions consisted of either a double Michael reaction or Michael–hemiacetal formation via the addition of fluorobis(phenylsulfonyl)methane (FBSM) to enals. The final products were obtained in good yields with excellent stereoselectivities.



November 2013: Xavi received a Marie Curie Intraeuropean fellowship for a postdoc in Imperial College (London).

Congratulations!!!! All our PhD students to date have received a Marie Curie fellowship after working with us!!! Congratulations Xavi Companyo and Andrea-Nekane R. Alba!!!!


November 2013: A New Review from our group is online:

Nucleophilic addition to carbon–nitrogen double bonds (imines) represents one of the most common strategies for the synthesis of amine derivatives. In order to circumvent the problem associated with low reactivity of imines in nucleophilic addition, various imines with electron-withdrawing groups at nitrogen have been studied, and many of them were successfully applied in asymmetric methodologies. Especially N-carbamoyl imines were found to be useful in the enantioselective synthesis of various organic compounds, due to their increased reactivity toward nucleophiles as well as limited difficulties connected with the removal of the carbamoyl moiety in target molecules. The aim of this review is to cover enantioselective methods based on N-carbamoyl imines, focusing on synthetically useful protocols.


November 2013: Our latest Tetrahedron paper is online:

Catalytic asymmetric one-pot synthesis of α-methylene-γ-lactams

An organocatalytic enantioselective synthesis of α-methylene-γ-lactams has been developed. The reaction between protected 2-aminomalonates and Morita–Baylis–Hillman carbonates is catalyzed by chiral Lewis bases to afford the corresponding lactams in excellent yields and moderate to good enantioselectivities, after work-up.


Congratulations: Xavi and Pierre!!!!!


November 2013: Our paper in the Asian Journal of Organic Chemistry: Enantioselective Organocatalytic Amination of Pyrazolones. Has been one of the top 25 most dowloaded papers!!!

November 2013: Our latest Tetrahedron Letter paper is online:


A new three-component cascade reaction for the synthesis of thiohydantoins is reported. The reaction between α-amino esters, nitrostyrenes, and aromatic isothiocyanates is efficiently promoted by organic bases to afford highly substituted thiohydantoins in moderate to good yields and diastereoselectivities.


Congratulations Victor, Kane and Marta!!!!


August 2013: Our book is published:

Stereoselective Organocatalysis: Bond Formation Methodologies and Activation Modes




January 2013: Our latest Chemical Communications paper is online:

All in one pot: an organocatalytic highly enantioselective synthesis of α-methylene-γ-lactones has been reported. The reaction between protected 2-hydroxymalonates and MBH carbonates is simply catalysed by chiral Lewis bases affording after acid treatment the corresponding lactones in excellent yields and enantioselectivities.

Graphical abstract: First one-pot organocatalytic synthesis of α-methylene-γ-lactones

Congratulations Xavi!!!


December 2012: Our latest Asian Journal of Organic Chemistry is online:

Enantioselective Organocatalytic Amination of Pyrazolones


Thumbnail image of graphical abstract

Easy as py: The organocatalytic enantioselective amination of pyrazolones is reported. The reaction between pyrazolones and diazodicarboxylates is simple and is catalyzed by quinine to afford the final aminopyarazolone derivatives in excellent yields and good enantioselectivity.

Congratulations: Jan and Marek!!!!

August 2012: We have moved at University of Southampton in August 2012.



Rios Group . Department of Organic Chemistry. University of Southampton, e-mail: R.Rios-Torres@southampton.ac.uk | Google Analytics | Stats |


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